O'Shea is the more likely to feature having trained this week following a calf injury, while leading scorer Fletcher will be assessed on Friday.
The Scot was forced off at half-time in last weekend's defeat by Norwich with an ankle problem and saw a specialist this week.
Captain Lee Cattermole is expected to be out for another two months after damaging knee ligaments.
Early Doors believes Jose Mourinho left Real More »
Early Doors - 6 hours agoAlong with the inevitable search for a new coach, More »
Pitchside Europe - 14 hours agoCheck out our pick of Europe's best players this More »
Pitchside Europe - 19 hours agoEvery season Tottenham go without leapfrogging More »
Early Doors - Mon, May 20, 2013 06:01 BSTEurosport's Andreas Evagora examines the More »
Pitchside Europe - Fri, May 17, 2013 17:59 BST