The Magpies, without a major trophy since 1969, will attempt to secure their passage to the last eight when Anzhi Makhachkala head for St James' Park on Thursday evening.
No British club has lifted the trophy in its various guises since Liverpool in 2000-01, and with Chelsea and Tottenham alongside Newcastle in the last 16, that is a situation which could well be remedied this season.
While Pardew know his side faces a tough task simply to find a way past the big-spending men from Dagestan - he has consulted Liverpool counterpart Brendan Rodgers, whose side beat Anzhi 1-0 at Anfield during the group stage of the competition, as part of his preparations - he is convinced that if they do it, they can go all the way.
He said: "We are in it to win it. There's no point saying to me, 'Would the quarter-finals be a great achievement for you in your managerial career?'
"It would be something I could put on my CV, but it wouldn't really mean much to me unless I win the trophy.
"I have been to the FA Cup final twice and lost twice, and I see this competition as a higher standard of competition.
"But I want to win and this club wants to win trophies, so we have a big agenda in front of us.
"There are some very, very good teams in this tournament and we are really looking forward to this game."