The Ayrshire club last week lost their appeal against the red card the skipper picked up in the opening minutes of their Clydesdale Bank Premier League defeat to St Johnstone.
The Scottish Football Association fast-track tribunal decision saw the Italian served with an automatic two-game suspension for serious foul play.
Pascali sat out last weekend's William Hill Scottish Cup win over Queen of the South and, as far as Shiels is concerned, has now been punished enough.
He said: "We are a bit bemused because we don't know whether Manuel Pascali is able to play or not. We will probably give it a go. He got two games and he missed the last 90 minutes of the St Johnstone game.
"He was sent off but he still missed 90 minutes so, to me, that's one game and he missed the ensuing game against Queen of the South. I think Manuel Pascali is available."
Shiels himself had until Wednesday to respond to two notices of complaint issued by the SFA's compliance officer last week. One of the charges relates to the Killie manager's reaction to Pascali's dismissal.
He has indicated he is likely to appear in person at Hampden on December 13 for the hearing into the two cases.
Shiels said: "I probably will. I think it's important that I defend myself to exonerate myself."
Looking ahead to the visit of Celtic on Saturday, he added: "Celtic are Celtic. They are always favourites in whatever game they play in. We would love to do well against them. Our result earlier in the season gives us something to build on and hopefully we can do well again because we've got really tough fixtures coming up."