The Seasiders' five-game unbeaten came to a crashing halt and Ince was quick to admit that a swashbuckling Brighton proved too talented for his tired players.
Will Buckley put the Seagulls ahead in the ninth minute after cutting inside and guiding a sweet finish into the top right-hand corner, before Matt Upson bundled his first Brighton goal over the line midway through the first half.
Andrea Orlandi, David Lopez and Ashley Barnes (2) all found the net as Brighton hit six, and an own-goal by Dean Hammond was Blackpool's only consolation on a miserable afternoon for Paul Ince's men.
He said: "When you come to places like Brighton you need to start well. We looked leggy and we looked tired from the first minute to the last. We couldn't cope with their pace and technique.
"We needed to stay in the game for longer than nine minutes and we never got to grips with them. We were second best all over the park.
"One thing you can't say is that we didn't show fight. Look at the turmoil these players have been through. These players have been fighting all their careers. We're not a club with £25million, a new stadium and a new training ground."
Ince has insisted that he will not allow his players to let the season fizzle out despite the club languishing below mid-table in the Championship.
He added: "I'm not the sort of person who will allow the season to fizzle out. Before this game we had conceded seven goals in our last 11 games, so to concede six in one game is disappointing.
"But it means we can say it was just a bad day at the office. We have two more games to go, and we need to have a scotch, go to sleep and forget about it."