The 30-year-old has shone on his first season as a Premier League player, netting 11 goals in 25 matches.
His haul is the highest by an English player and led one bookmaker to offers odds of 3/1 on him receiving a first call-up for this week's match against Brazil.
In the end, England boss Roy Hodgson overlooked the striker, something Pochettino was relieved about after left-back Luke Shaw picked up a knock on England Under-21 duty.
"For me, they are all worthy of playing for their national teams," Pochettino of his new charges.
"[But] it would be better for Southampton that they are not with their national teams after what happened to Luke Shaw.
"It's natural they should have enthusiasm to play for national team, but they have to be calm and everything comes bit by bit over time."