John Terry is still serving a four-match ban for racist language, leaving Chelsea stretched at the back, although left back Ashley Cole has recovered from a swollen ankle. Frank Lampard is still sidelined with a calf injury.
Swansea are sweating on the fitness of defender Chico Flores after he limped out of Wednesday's League Cup victory at Liverpool while German Gerhard Tremmel will continue in goal in the absence of first-choice Michel Vorm who was injured in the defeat by Manchester City last week.
Argentina full back Pablo Zabaleta's return to fitness is a boost for Manchester City as they travel for the late kick-off at West Ham United.
Zabaleta has been hit with a hamstring injury but is expected to return to the right back slot after Micah Richards was injured in the 1-0 home victory against Swansea City last week.
Fourth-placed Tottenham Hotspur will again be without injured midfielder Moussa Dembele as they host Wigan Athletic on Saturday but striker Emmanuel Adebayor returns to the squad after a stop-start season.
Fifth-placed Everton hope to have Belgian midfielder Kevin Mirallas fit for the trip to Fulham despite picking up an ankle injury against Liverpool last week.
Click the links below for full previews from the weekend's games, including team news, manager quotes and match facts from Opta. Kick-offs 15:00 UK time unless stated.