Midfielder Pugh, on loan at Hillsborough since January, played at left-back in the midweek win at Millwall. He could be replaced in the starting line-up by Reda Johnson.
Johnson was rested in midweek as he continues to manage an ongoing foot problem, while manager Dave Jones could also recall on-loan Bolton midfielder Stuart Holden and winger Jermaine Johnson, who played for the final 30 minutes at Millwall.
Jones, who has no new injury or suspension worries, must decide whether to recall all three for the derby clash, while the likes of midfield pair Rhys McCabe and Jose Semedo and defenders Joe Mattock and Martin Taylor are all in contention.
The Owls, six points above the relegation zone, have won four of their last six matches and virtually assured themselves of npower Championship football next season with victory on Tuesday night.