England midfielder Wilshere has been ruled out for three weeks with an ankle injury, and will also miss England's World Cup qualifiers against Montenegro and San Marino.
The 21-year-old has been in a rich vein of form, and his absence is a real blow for Arsene Wenger as his side look to try to make up the deficit to the top four and secure a Champions League place for next season.
But Arsenal were able to win 2-0 without Wilshere at Bayern Munich in midweek, and even though it was not enough to send them into the last eight of this season's Champions League, Rangel believes the result shows the depth of quality in their squad.
He said: "Arsenal are a team with a lot of very good players.
"Santi Cazorla has been a top player for them all season, and Theo Walcott has so much pace and he is scoring plenty of goals.
"Wilshere is out but they have other players doing well like Mikel Arteta.
"They are not just about one player, they are all very comfortable on the ball and it will be a game with a lot chances I think.
"I am sure it will be a great game for the fans but hopefully being at home can make the difference for us."