Guedioura has been away with Algeria at the African Nations Cup and returned to England with a bug. He has not trained this week but caretaker manager Rob Kelly will check on the midfielder.
Kelly, in charge following this week's departure of Alex McLeish and ahead of Billy Davies' return as boss, will also assess Daniel Ayala ahead of the trip.
The on-loan Norwich centre-half has been absent with a hamstring injury but is making progress in his recovery.
The game sees Kelly go up against former Reds manager Sean O'Driscoll, who was controversially sacked by Forest's Kuwaiti owners on Boxing Day following a 4-2 home win over Leeds that left the club just one point outside the play-off places.