Centre-half Reid was forced out of Friday's home win over Leyton Orient just before the interval and replaced by David Mirfin.
Mirfin had been dropped to the substitutes' bench, but formed a solid partnership alongside Niall Canavan and the pair will continue if Reid is ruled out.
Manager Brian Laws recalled Andy Barcham against Orient and must decide whether to retain him on the wing or recall on-loan Wolves teenager Anthony Forde.
Striker Akpo Sodje struck his 13th goal of the season on Friday - his sixth in 12 appearances for Scunthorpe - and will continue up front alongside Karl Hawley or Stoke loanee James Alabi.
The Iron have extended Manchester City goalkeeper Eirik Holmen Johansen's loan spell until the end of the season and he will continue in the absence of Sam Slocombe, currently sidelined with a torn thigh muscle.