Roberts, 35, missed the 2-1 home win over Leicester prior to the international break due to a calf injury.
The player was pencilled in to start Tuesday afternoon's development squad match against Coventry but had to withdraw shortly before kick-off after feeling his calf tighten during the warm-up.
Midfielder Craig Forsyth will continue to deputise at left-back should Roberts not be available.
Rams boss Nigel Clough is keen to extend Forsyth's loan spell from Watford. His one-month deal expires after the trip to Leeds on Monday.
Leading scorer Jamie Ward (hamstring) and midfielder Craig Bryson (groin) have come through a full week of training unscathed and will be available for selection. Both players have been nursing minor niggles in recent weeks.
Kieron Freeman, who limped off against Leicester 12 days ago, is also fully fit while fellow defender James O'Connor made his comeback from an ankle injury in the development squad this week and could be included in the squad.
Chris Martin will feature after his loan deal was extended until the end of the season and the Norwich striker is expected to partner Conor Sammon in attack.
Teenage midfielder Will Hughes (groin) and right-back John Brayford (hamstring) are making progress in their recoveries but Friday night's game will come too soon for both of them.