Fresh speculation surrounding the Uruguay striker has begun just days after he appeared before Liverpool's opening home game of the season apparently content to remain at Anfield for the time being.
But with Real Madrid - the club top of Suarez's list when he first sought a transfer earlier this summer - linked with a move for him, Rodgers said there was no longer enough time remaining in the transfer window to countenance losing last season's top scorer.
"It's very difficult at this time [for a Suarez bid to succeed]," Rodgers said. "We are trying to get one or two more quality players in through the door. If we lose Luis at this stage it would be difficult to replace him.
"There might have been a point a few months ago where there was time to do it but with 11 days to go it would be difficult to replace him."
The Reds were keen on the highly rated Henrikh Mkhitaryan but lost out to Champions League finalists Borussia Dortmund while interest in Atletico Madrid striker Diego Costa came to nothing.
Now Anzhi Makhachkala's Brazilian forward Willian appears to have snubbed Anfield but Rodgers, whose side impressed in their season-opening defeat of Stoke, is not perturbed.
Rodgers said: "Over the course of the summer we have been very ambitious in our attempts to improve the team. Some might say too ambitious - but this is Liverpool Football Club.
"We are trying to get the best players we possibly can. If we can't get them in we just have to move on. We have 11 days to go. We have to do everything we possibly can. It hasn't changed."