Southampton are back in the top flight after a seven-year absence and are starting to impress after a difficult start to the campaign, hovering just above the relegation zone.
Nigel Adkins takes his side to fellow strugglers Aston Villa, whose recent problems were epitomised by Tuesday's shock 3-1 defeat to Bradford in the Capital One Cup semi-finals.
Southampton will be looking to compound matters and jump above the midlanders with victory - a result Rodriguez believes his side are more than capable of.
"We have a inner confidence and team spirit so we can go to places and get a good result," the striker said. "I am sure that we will.
"We are working hard every day in training, getting the right stuff on board getting ready for the games.
"I think we will go into the game with inner confidence.
"We've done very well this season and I think we have been unlucky on certain occasions not to get the three points.
"I feel we have got a self-belief, a team spirit, and feel we are going to go forward.
"We are picking up points on the road as well, which is better. We know we need to keep working hard, keep focused and hopefully keep moving up the table."