Sylvestre replaced Neal Eardley at half-time during last weekend's comeback victory over Watford, while Matt Derbyshire made way for fellow forward Delfouneso before a 1-0 deficit turned into a 2-1 triumph.
Boss Paul Ince will hope to build on his first victory in charge on the Seasiders' return to Bloomfield Road, but he must once again do without Gary Taylor-Fletcher (hamstring), Bob Harris (toe) and long-term victim Ian Evatt (knee).
Defender Kirk Broadfoot is eager for Blackpool to build on their weekend success.
"With the players that we have got here, I believe we can beat anyone on our day," he told the club's official website.
"We went down there with confidence and a game plan with how we wanted to set up. It worked and we got a good result.
"We are just happy that we could get three points at a very difficult place and we can now look forward to the game on Saturday."