The Reds manager is still sweating on ankle-knock victim Niall McGinn after the Northern Ireland striker missed out on last week's 3-0 win over Partick Thistle with a knock sustained on international duty.
But while the Pittodrie men welcome an Inverness side to the Granite City who boast a record of five wins and a draw from six Scottish Premiership fixtures so far, McInnes is not overly concerned by his lengthy list of absentees.
He told RedTV: "We are playing a very good confident Inverness team - but we beat a confident Partick team last week.
"Although we have injuries we showed last week we can cope. We have to go out and try impose ourselves. It is a challenge but a challenge I think we are ready for."
The good news for McInnes is that his injury concerns are starting to ease.
"We are getting Niall McGinn scanned today and will see how he is," he explained.
"Niall is feeling a lot better within himself but obviously we will not be taking any risks and we will see how the injury measures up medically. Fingers crossed it is improving.
"Barry Robson is still looking to be involved. We have not ruled him out yet. If we can get one back out of the two boys that would be a huge boost for us.
"Russell Anderson's hand is still in plaster and we will have a look at it again next week to see if we can put on a lighter cast which would allow him to play.
The only blot Caley Thistle's impressive record so far is the two-goal lead they let slip at Celtic Park, allowing the Scottish champions back in to snatch a point.
McInnes only has respect for the Highlanders' boss Terry Butcher and he admits his team are now setting the benchmark which the Dons must aim to beat.
"I did my pro licence alongside Terry Butcher and worked closely with him for two years," said McInnes.
"When you work with people as closely as that you get to know them well. He was always good company.
"Saturday is a big game because we are playing the team top of the league. Huge credit to them for the way they have started.
"There has been quite a big change to their squad and Terry has brought some good players in this summer.
"He has had a consistency in selection which always helps - I think I am right in saying he has played the same team in the league every fixture.
"If we are in and around Inverness at the end of the season I think it will mean we have done pretty well. They are a good side with a good manager.
"They had disappointment last season losing to Hearts in the League Cup semi-final and missing out on Europe on the last day of the campaign but overall, what is happening up there is a great story."