The 30-year-old defender left the field after 43 minutes of last weekend's 1-1 draw with Gillingham and is not expected to recover in time to face the Dons.
Robbie Threlfall was his replacement against the Gills and the former Liverpool trainee is manager Jim Bentley's likely selection.
Bentley will also be without Kevin Ellison who will serve the second and final game of his suspension after picking up 10 bookings this season.
Andy Parrish is a further absentee as he continues to struggle with a thigh injury.
The Shrimps have taken the lead in all of their last three games but failed to win any, ending their slim play-off hopes.