Smith, the four-goal hero of Latics' run to the fifth round of this season's FA Cup, has not featured in the last two matches after suffering severe bruising to his knee in the 1-0 defeat to Tranmere but is now back in full training.
Bobby Reid is pushing for his Oldham debut having signed on loan from Bristol City earlier this week, while former Leeds and Swansea full-back Federico Bessone could feature against the club he left earlier this season after completing a move to Boundary Park on Thursday afternoon.
Boss Lee Johnson has also added rookie defenders Glenn Belezika and Joe Cooper to his travelling party. The duo impressed for the reserves against Hull in midweek.
A combination of postponements and their cup run means the County Ground clash will be the first of nine games in 30 days as Oldham look to secure League One safety.