Smith, who scored four goals during Latics' run to the fifth round of this season's FA Cup, jarred his knee during Saturday's 1-0 defeat at Tranmere.
Swelling around the joint raised concerns and the 23-year-old striker will undergo a scan.
Midfielder James Wesolowski is fit to play despite having six stitches in a head wound sustained at the weekend and his presence may mean bench duty once more for club captain Dean Furman.
Cliff Byrne remains a major doubt and the experienced defender had an injection on Monday to help speed up his recovery from ankle ligament damage.
Youssouf M'Changama (knee) remains a long-term injury victim.