Veteran defender Efe Sodje has returned from his loan spell at Barrow and will go straight into the squad to face Boro.
Blackwell has no new injury or suspension concerns following Saturday's 2-1 home defeat to 10-man Colchester but is primed to ring the changes to prevent a fifth consecutive home defeat.
Nick Ajose came on to replace Carl Regan at half time against the U's and is first in line for a recall, while Peterborough loanee Jonson Clarke-Harris will also hope to earn a starting spot.
Still restricted by a transfer embargo, Blackwell is also hindered by a number of long-term injuries.
Tom Soares (hamstring), Phil Picken (knee), Adam Lockwood (groin) and Shane Byrne (blood infection) are all ruled out until next season.