The in-form forward suffered a groin injury when challenging former team-mate Stephen McManus last weekend and he is highly unlikely to return to action against Dean Saunders' men.
But with the exception of the former Blackburn striker, head coach Sean O'Driscoll has a lot more options for the trip as Louis Carey is back in full training and Paul Anderson has recovered from the bug that kept him out of the win over Middlesbrough.
And with striker Sam Baldock having recovered from a calf strain and Albert Adomah impressing as a replacement for Stead last weekend, O'Driscoll has plenty to ponder ahead of kick-off.
"I have more options now and you need that," he told Press Association Sport. "Every team is going into the last eight or nine games of the season with injury as the big worry, and keeping people fit. You are not going to change your squad that much.
"We lost three players on Saturday morning and the more players you have to select from to help with those problems the better."
City and Wolves, 24th and 23rd in the npower Championship, are just separated by goal difference.