Vaughan lost a tooth in the goalless weekend draw with Cardiff and is doubtful, while on-loan Jermaine Beckford (hamstring) is still sidelined and would not have had permission to play against his former club anyway.
Another forward, Lee Novak, is still not fit after missing out on Saturday with a toe injury, so caretaker managers Mark Lillis and Steve Eyre are hoping Vaughan recovers in time to partner Sean Scannell up front.
Midfielder Neil Danns is another Leicester loanee who will play no part, so Chris Atkinson or Jordan Sinnott will vie for a recall to the starting line-up, while goalkeeper Alex Smithies is expected to retain the captain's armband in the absence of defender Peter Clarke (concussion).
Oscar Gobern is unlikely to be involved due to a tight hamstring. The midfielder returned to contention following summer ankle surgery for the first time this season in the recent defeat at Derby, but was not involved against Cardiff.
Winger Danny Ward (foot) and midfielder Keith Southern (Achilles) remain sidelined.