Taylor-Fletcher appeared as a late substitute as the Seasiders beat Lancashire rivals Burnley 1-0 at Bloomfield Road on Saturday, having been on the sidelines since the start of last month with a hamstring injury.
Midfielder Isaiah Osbourne serves the second game of a three-match suspension but, aside from long-term injury absentee Ian Evatt (knee), boss Paul Ince has no other selection problems.
Ludo Sylvestre netted a superb winner against the Clarets and will go in search of a third goal in as many matches versus Wednesday.
"The thing is that even if I scored with my shin pad it's a goal too so I am just happy for everybody," he told Blackpool's official website when discussing his current purple patch.
"The gaffer believes in me, which is always nice and this gives me confidence and I just want to keep going, playing football."