Lancashire neighbours Blackburn made an official approach to speak to Appleton on Wednesday night and the former Portsmouth boss was absent from training on Thursday, with assistant Steve Thompson taking the session.
Taylor-Fletcher suffered a back injury during last weekend's draw at Fulham in the third round of the FA Cup and faces a late fitness test.
Blackpool would be lightly stocked in attack if the former Hull man misses out, following Wes Thomas' return to Bournemouth at the conclusion of his loan spell at Bloomfield Road and Matt Phillips' (toe) continued injury absence.
Centre-back Ian Evatt remains on the sidelines due to bone bruising to his knee.
