Veteran striker Kevin Phillips was rested among the substitutes at Peterborough last weekend having started the Seasiders' previous three npower Championship matches.
His replacement, Wes Thomas, marked a first start since joining on loan from Bournemouth with the opening goal in a 4-1 victory.
Fellow forward Gary Taylor-Fletcher is stepping up his recovery from a hamstring injury, but this weekend may come too soon for him.
Winger Matt Phillips (toe) and defender Ian Evatt (knee) remain sidelined.
The Selhurst Park showdown will be the first time Blackpool have encountered former boss Ian Holloway since his surprise decision to leave the Fylde coast for the capital at the start of last month.