Defender Bruno missed Saturday's goalless draw at Nottingham Forest with an Achilles injury and has been ruled out again.
His countryman Inigo Calderon is set to deputise at right-back once more despite picking up a knee knock at the weekend.
Orlandi is recovering from a broken rib and fellow midfielder Vicente remains sidelined due to a thigh problem, with both likely to be out until the new year.
Gary Dicker is still struggling with the knee injury he suffered in training last week and the midfielder is likely to miss out again.
Boss Gus Poyet could therefore name an unchanged side as they look for a first win in four matches.