Until the former Team Bath manager arrived at St James Park the Grecians had gone 18 years without a competitive victory over Plymouth, their biggest rivals.
Having ended that drought with a dramatic late win at Home Park in 2010 Tisdale oversaw two wins from their next three meetings before taking just one point from the two fixtures last season.
The Exeter boss knows exactly what to expect as he prepares to welcome the out-of-sorts Plymouth in Saturday's lunchtime kick-off.
"I understand the importance of the game to both clubs and the people who support Exeter every week and see this game as a particularly exciting and interesting game," he said.
"I recognise that myself, I recognise the importance of it.
"They will be tough opponents and I don't think it will be any surprise if we have a competitive game, that is what we are assuming and I will be amazed if it is anything different.
"Form tends to go out of the window and who knows what will happen? We go into every game expecting to win and we will do our very best in the game."