The Grecians' play-off hopes were ended by a 1-0 defeat to Cheltenham last weekend which means nothing is riding on this final match of their season.
And the Exeter boss has confirmed he will use this as an opportunity to field some of his younger players to continue their development ahead of next season.
With Steve Tully having used painkilling injections to play through the pain of a broken toe in recent weeks, Aaron Dawson looks set to step in at right-back while Jake Gosling, Jamie Reid and Jordan Moore-Taylor are all pushing for starts.
Anton Rodgers is also likely to be given a chance in the Exeter midfield having only made one appearance since joining the club from Brighton.
Liam Sercombe and Matt Oakley remain out while Tisdale may chose to leave out experienced duo Tommy Doherty and Alan Gow who have not been fully fit in recent weeks due to injury.