The U's travel to Sixfields knowing defeat could leave them nine points adrift of the top seven with six games remaining.
And Wilder could include Jon-Paul Pittman on the bench after the forward returned to training following his dislocated shoulder.
The former Crawley and Wycombe forward has been missing since December and he looks set to feature in the matchday squad.
Oxford have lost just two in their last eight games but their play-off hopes suffered a blow when Chesterfield won 1-0 at the Kassam last weekend.
The U's remain without long-term injury victims goalkeeper Ryan Clarke (shoulder), striker Justin Richards (knee) and midfielder Peter Leven (knee).