The Serbian defender missed United's tour of Australia and the Far East with a back complaint but came through 62 minutes untroubled at Gresty Road.
There were also run-outs for Nani and Antonio Valencia who both missed the trip, with Nani scoring both goals.
The Portugal international, who has been suffering with a broken nose, slotted in a first-half free-kick and then tucked away a second goal after the break.
Gonzalo Higuain and Pepe Reina were presented to the fans ahead of Napoli’s 3-1 win over Galatasaray, but did not make their debuts because the international transfers had not yet come through.
Juan Camilo Zuniga, Lorenzo Insigne and Goran Pandev scored in a match which was originally set to be a huge celebration with cheerleaders, fireworks and dance routines but was pared down out of respect after a bus crash on Sunday killed at least 37 people in nearby Irpinia.
A minute’s silence was also held in their memory before the game.
There were wins for Premier League sides West Brom and Hull.
The Baggies fell behind to an 11th-minute goal at Shrewsbury’s Greenhous Meadow scored by Athanasios Karagkounis of Greek side Atromitis, but they recovered to win 3-1.
Nicolas Anelka came on at the break and took just 10 minutes to equalise - heading home his third goal in as many friendlies – before 19-year-old striker Saido Berahino hit the bar then scrambled home minutes later for 2-1.
Markus Rosenberg was again on target, three minutes from time, to complete a third straight win.
Maynor Figueroa’s bullet strike into the top corner on 33 minutes was enough for the Tigers to beat Peterborough 1-0 at London Road, with George Boyd featuring at his old stomping ground for the first hour.
Crewe 0-2 Manchester United XI
Kitchee 2 - 5 Manchester United
West Bromwich Albion 3 - 1 Atromitos
Peterborough 0 - 1 Hull
Shelbourne 0 - 4 Leeds
Forest Green 3 - 5 Yeovil
Napoli 3 - 1 Galatasaray
L. Leipzig 1 - 2 Schalke 04
Hallescher FC 0 - 1 Hannover 96
Bari 0 - 0 Apollon Limassol
Kayserispor 1 - 1 Rizespor
Ayr 0 - 2 AEL Limassol