Spurs can cap a near-perfect festive period with a New Year's Day victory at White Hart Lane after ending 2012 with seven Barclays Premier League points from nine.
The only blip was another disappointing home result, a goalless draw with Stoke that preceded victories at Aston Villa and Sunderland.
That was also one of only two occasions Tottenham have failed to win in their final nine matches of the year in all competitions, their best run of results since Villas-Boas took charge in the summer.
Spurs will be expected to brush aside a Reading team they beat comfortably in September's reverse fixture, but their patchy home form this season suggests victory cannot be taken for granted.
"The problem with that fixture is that we have done extremely well away from home, but we have to keep up the momentum," Villas-Boas said.
"We have to keep our home form going and it would be silly for us not to continue at this level, so it is a fixture in which we really want to get the three points to close finally the festive fixtures with three wins, hopefully, and one draw."
Villas-Boas hailed his players as "magnificent" over the past month.
He added: "They have been excellent. The December that we had shows exactly that.
"We had big, big results against difficult teams and the Europa League in between. If we manage to take this form into January, it would be excellent."