The U's went down 4-0 at home to Rotherham on Tuesday night and Wilder admitted he selected the wrong system against the Millers.
He introduced Josh Parker and Scott Davies at the half-time interval with his team already 4-0 down and the pair are pushing for inclusion from the start at Plainmoor.
Strikers James Constable and Tom Craddock are other options as Oxford look to get back to winning ways.
One player who will not feature is midfielder Adam Chapman who moved on loan to Mansfield until the end of the season on Wednesday.
Goalkeeper Ryan Clarke, (shoulder) striker Justin Richards (knee) and midfielder Peter Leven (knee) remain sidelined.