Boro slipped out of the top flight at the end of the 2008-09 campaign and have undergone a major financial restructuring during the four seasons since.
They currently lie in fifth place in the npower Championship, just three points adrift of second-placed Leicester, and Mowbray believes the evidence is there to prove that they would not have to break the bank to cope if they did go up.
He told the club's official website, www.mfc.co.uk: "I think any team that gets out of this league can be competitive in the Premier League.
"The Championship is very competitive and hardens you up for the Premier League. When you get there, players will take confidence from West Ham, Swansea, Norwich and West Brom, who have gone in and stayed there and prospered.
"The danger for me would be to think you have got to spend £50million to stay there once you go up - Norwich City have shown you don't need to do that."