The defender has been ruled out for up to nine months after damaging his anterior cruciate ligament in the 4-1 defeat to Bradford in midweek.
Youngster Ollie Clarke could be handed a full debut in his place after coming off the bench at Valley Parade and impressing boss John Ward.
Skipper Tom Parkes is available after completing his two-match ban, while striker Oumare Tounkara and winger Ellis Harrison are expected to return after missing the midweek defeat due to knocks.
Ward's men must win if they are to keep their slim hopes of a play-off place alive. They currently trail seventh-placed Bradford by six points - and have a much inferior goal difference - with just three games left to play.