The midfielder has missed his side's last two games after he was knocked unconscious against Notts County on April 13, but he is back in contention after making a speedy recovery.
Dunne will check on defender Josh Thompson (hamstring) and Clinton Morrison, who is rated as doubtful after he strained a quad muscle in training.
The U's currently sit 20th in npower League One, three points above Scunthorpe in 21st, so a point would be enough to stave off relegation to the country's fourth tier.
Dunne told the club's official website: "Scunthorpe can win as long as we pick up a positive result - and a positive result is what we're aiming for.
"We've spoken about the game at training and, in a way, it's good that we have total clarity on what needs to happen.
"It helps us, because we have to get something and that's better for my team based on recent results since January. When it's absolutely necessary and when we have a clear task in hand, we've responded."