FOM said the NBC Sports group will broadcast all 20 races of the 2013 season - four on NBC and 16 on NBC Sports Network - as well as practice sessions and qualifying.
NBC replaces Speed as the Formula One broadcaster in the US after a 17-year run.
"NBC and its various media assets have a huge profile throughout the United States and I am obviously delighted to have concluded this agreement," said F1 supremo Bernie Ecclestone.
"I feel that they will promote Formula 1 to a level not seen before in the United States.
"I very much look forward to working with NBC. Together, we will endeavour to broaden the scope of Formula One coverage available to US viewers incorporating additional digital content in particular that has not been available before."
The Canadian Grand Prix and the final three races of the year will air on NBC, while the remaining events will be broadcast on NBC Sports Network.
"We are thrilled to add the top international open-wheel racing series to our already-strong motorsports portfolio," said Jon Miller, President, Programming, NBC Sports and NBC Sports Network.
"Formula One is a perfect fit for the NBC Sports Group as it provides content across three platforms - broadcast, cable and digital - for nine months a year with more than 100 hours of premier programming annually."