First-half goals by 18-year-old midfielders Sammy Stanton and Danny Handling, both making their first starts, gave the visitors a comfortable interval lead.
Handling grabbed his second after the break with substitute Ross Caldwell completing the scoring.
Manager Pat Fenlon made 10 changes to the starting line-up that had lost in Leuven on Saturday with only Alan Maybury retaining his place, although he was switched to right-back from midfield.
Hibs' early dominance paid off after 24 minutes when Jorge Claros' insightful pass paved the way for Pa Kujabi to get to the by-line and his cross was knocked into the net by Stanton on the second attempt.
The Easter Road side doubled their advantage after 37 minutes when Handling met Griffiths' cross at the back post to score from close range.
There was still time for the lively Paul Cairney to see his goal disallowed for offside before the interval.
After the break, Hibernian moved up a gear and Handling struck again with a low right-footed shot into the far corner of the net to make it 3-0.
The fourth goal arrived when Handling found Caldwell, who steered his shot into the net from close range - his second goal of the three-game overseas tour.