All matches kick off at 19:45 unless specified
Aston Villa v Tottenham
Aston Villa boss Paul Lambert is set to make sweeping changes to his line-up. Gabriel Agbonlahor and Antonio Luna are almost certain to sit out after returning from injury problems in Saturday's Premier League win at Norwich. Jed Steer is set to replace Brad Guzan in goal and there are also expected to be starting places for the likes of Nicklas Helenius and Yacouba Sylla.
Tottenham manager Andre Villas-Boas will ring the changes at Aston Villa. The Spurs boss has expressed his frustration that the fixture takes place just two days after their Premier League win in Cardiff, and very few who featured in south Wales are likely to start at Villa Park. The likes of Brad Friedel, Erik Lamela, Lewis Holtby, Sandro and Vlad Chiriches could all start, but Jermain Defoe is a doubt due to a groin strain.
Hull City v Huddersfield
Hull manager Steve Bruce will ring the changes once again for his side's third round clash against his former club Huddersfield. Bruce's starting XI against Leyton Orient last time showed a full 11 changes from the Tigers' previous league match and with James Chester (hamstring) the latest of his first-team squad to suffer injury, he could follow the same plan at the KC Stadium. Senior men may take a place on the bench but the likes of Alex Bruce, Abdoulaye Faye, Connor Henderson, Matt Fryatt and Nick Proschwitz will be hoping to start, while Steve Harper is on hand to replace Allan McGregor in goal.
Huddersfield are expected to be without injured defender Joel Lynch. Lynch was withdrawn from Saturday's goalless draw at Blackburn after taking a bang on the knee and his replacement Calum Woods could return to the starting line-up. Winger Danny Ward hopes to shake off an ankle injury sustained last week in training in order to stake his claim, while manager Mark Robins has confirmed he will make several changes with Friday's home league game against Blackpool in mind. Midfielders Oliver Norwood and Oscar Gobern, plus striker Sean Scannell are among those hoping to feature and Robins, who has no other selection issues, could hand several youngsters a chance to shine.
Manchester City v Wigan
Manchester City defender Micah Richards could make his first appearance of the season in the tie against Wigan. Richards has missed the start of the season with hamstring trouble but was an unused substitute in the weekend derby win against Manchester United. Midfielder Jack Rodwell missed that game with a knock and could be doubtful while playmaker David Silva (thigh) and defender Gael Clichy (thigh) continue to be assessed. Changes are probable with the likes of Joleon Lescott, James Milner and Stevan Jovetic pushing for places.
Owen Coyle claims there will be no bluffing from him as he selects a Wigan XI for the third time in six days to face Manchester City in the League Cup. And Coyle confirmed that with Shaun Maloney, Grant Holt and Marc-Antoine Fortune still not fit enough to return at the Etihad Stadium, Wigan will boast a youthful side which could feature the likes of goalkeeper Lee Nicholls, midfielder Adam Buxton and forward Nouha Dicko.
Southampton v Bristol City
Southampton manager Mauricio Pochettino has a near full-strength squad to choose from. Danny Fox is the only injury absentee with an ankle knock, though fellow left-back
Bristol City will be without defender James O'Connor when they head to Southampton for their Capital One Cup clash. The Robins have yet to enjoy a league victory this season but have found their form in the cups with victories over Gillingham, Bristol Rovers and Crystal Palace. But they travel to St Mary's without O'Connor who will have a scan on an injury on Wednesday, one which is expected to sideline him for months. Louis Carey has a bug and will not feature while Aden Flint and Marvin Elliott are carrying knocks. Head coach Sean O'Driscoll is unlikely to make many unforced changes apart from Marlon Harewood and Elliot Parish, who have featured in their cup victories.
Almen Abdi remains on the sidelines for Watford's third-round clash at home to Norwich. The midfielder has missed the club's last three matches, including Saturday's 5-1 demolition of Barnsley, with a foot injury and will again watch from the stands when the Canaries come to town. Long-term absentees Nyron Nosworthy (Achilles) and Tommie Hoban (ankle) remain unavailable although the former has returned to training. Boss Gianfranco Zola is likely to make changes for the cup tie as the Hornets aim to make the fourth round for the first time since 2008.
Striker Gary Hooper will make his full debut for Norwich in Tuesday's Capital One Cup third-round clash at Watford. Team captain Sebastien Bassong limped out of the Canaries' defeat to Aston Villa with a hamstring problem and will therefore not feature against the Championship side. Striker Ricky van Wolfswinkel (toe) is unavailable and Elliott Bennett is out with cruciate ligament damage, but 18-year-old forward Josh Murphy could make his debut for Chris Hughton's side.
West Ham v Cardiff
West Ham are without suspended midfielder Mark Noble. Noble picked up a one-match ban after being sent off for two bookable offences in Saturday's loss to Everton. Midfielder Joe Cole (hamstring) and winger Stewart Downing (leg) are improving but are not yet ready while manager Sam Allardyce has suggested it is still too soon for striker Mladen Petric to start. Striker Andy Carroll (heel) and midfielder Alou Diarra (knee) are out.
Cardiff boss Malky Mackay is set to make a host of changes to his side. The likes of Nicky Maynard, Mark Hudson, Joe Lewis, Don Cowie, Jordon Mutch and Craig Noone are all be in contention to feature at Upton Park, while Mackay could opt to hand new signing Peter Odemwingie a first start. Andreas Cornelius is unlikely to be involved as the striker works to recover from the ankle injury picked up in the last round at Accrington.
Fulham v Everton (20:00)
Fulham boss Martin Jol is seeking a morale-boosting victory in the all-Premier League clash with Everton at Craven Cottage. While many top-flight bosses use the League Cup as an opportunity to rotate their squad, Jol is planning to send out a full-strength line-up which could be bolstered by the returns of striker Dimitar Berbatov, defender Aaron Hughes and midfielder Bryan Ruiz. Berbatov (hamstring), Hughes (thigh) and Ruiz (ankle) missed the trip to Stamford Bridge, along with defender Matthew Briggs (hernia) and first-choice goalkeeper Maarten Stekelenburg (shoulder), who are both still out.
Everton manager Roberto Martinez is ready to put faith in his squad as he plans to rotate players. However, the Spaniard will not be fielding a second-string side as Craven Cottage as it is likely midfielder Darron Gibson will make his long-awaited return from injury. He also insists loan-signing Romelu Lukaku is fully fit after a head injury and is raring to go again after scoring in the 3-2 win at West Ham. Martinez believes the fact they are facing fellow Premier League opposition will make it slightly easier in terms of preparation but he will be resting some of his more important players regardless despite there being almost a week until their next league match on Monday.