Hartlepool's League One clash with fellow strugglers Portsmouth was one of the first postponed due to a waterlogged pitch.
The Victoria Park surface failed a second inspection and referee Darren Bond had no other option but to call the game off.
A statement on the Hartlepool website read: "Today's game with Portsmouth has been postponed after referee Darren Bond carried out a second inspection of the Victoria Park pitch.
"Heavy rain throughout the week has left the playing surface extremely wet and more showers this morning caused concern for the match official.
"With forecasts suggesting further heavier rain is on the way later this morning and in to the afternoon - and with the knowledge of visiting fans making a long journey - the referee felt there was no alternative but to call the game off."
There is no new date for the game as yet.
Also off in the third tier is Brentford v Stevenage. "Referee Simon Hooper inspected the pitch in the last 15 minutes and has deemed it unplayable," read a statement.
Meanwhile, the League Two schedule was hit heaviest of all with numerous postponements with Accrington v Plymouth the only 3pm kick-off to survive an inspection.
League One
Hartlepool v Portsmouth
Brentford v Stevenage
Scunthorpe v Carlisle
Crewe v Bournemouth
Notts County v Leyton Orient
Doncaster v MK Dons
League Two
Bristol Rovers v Rotherham
York v Gillingham
Wycombe v Bradford
Torquay v Exeter
Morecambe v Dagenham
Oxford Utd v Fleetwood Town
Port Vale v AFC Wimbledon
