Thiago strained knee ligaments at the end of September, but is on the brink of a return after almost eight weeks out.
Adriano suffered a thigh strain earlier this month. He is close to a comeback after a three-week absence.
Barcelona booked their spot in the Champions League last 16 with a 3-0 win at Spartak Moscow on Tuesday.
They hold a three-point lead over Atletico at the top of La Liga