Real Valladolid scored the deciding goal in the 63rd minute. Manucho slotted home into the lower right of the net after intercepting Mikel Rico's pass and finishing the move with a left-footed shot.
With 18 points Real Valladolid trail Real Betis by one for the final Europa League spot, and have compiled a record of five wins, five losses and three draws on the season. Granada CF are in 17th place with a record of three wins, eight losses and two draws.
Real Valladolid controlled the ball for the majority of the match, and finished with a possession rate of 62.4%.
Real Valladolid's ball control tactics produced 10 shots, including five on target, while also drawing 14 free kicks from fouls and four corners.
They also completed 460 passes and had 19 crosses in the win.
The four attempts by Manucho were the most of any Real Valladolid player.
Antonio Rukavina's 15 passes to Jesús Rueda were the most of any Real Valladolid teammates during the match.
Granada CF enjoyed possession for 37.6% of the loss. Granada CF had 14 shots, including one on target.
Floro Flores made his mark on the match for Granada CF after coming on for Fabián Orellana in the 68th minute, as he took three shots.
Toño stopped four shots.
Orellana had four shots for Granada CF, more than any of his team-mates.
The combination of Guillherme Siqueira to Dani Benítez was the most common during the match, as the two players connected 18 times.