Argentina striker Lopez has scored 54 goals for Lyon in 102 Ligue 1 appearances since arriving from Porto in 2009.
And with Nicklas Bendtner out for three months, Juve manager Antonio Conte has the 29-year-old near the top of his January shopping list according to Tuttosport.
Lopez has 18 months remaining on his current deal at the Stade Gerland, and is believed to be ready to seek pastures new.
While a return to Argentina with first club Racing Club to end his career appears likely, seven-times-capped Lopez may seek one more challenge at the top level.
And a possible move for Lopez this month could be followed in the summer by Labidi, whom Juve have reportedly offered a three-year deal from next season.
The 17-year-old plays for Lyon reserves but is a France under-19 international and the Ligue 1 side hope to agree a new deal ahead of his current contract expiring in June.