The Argentine left-back, 29, consulted a specialist in Paris on Tuesday and will undergo surgery on Thursday afternoon, the Breton club said.
Mareque, who joined Lorient at the start of last season, missed the last match against Lyon after complaining of adductor pain.
The diminutive attacking full-back has made 32 Ligue 1 appearances for Lorient since joining from Independiente.
Lorient currently lie fourth in the French top division, five points behind leaders Marseille.
