Monaco came from behind to end Marseille’s unbeaten start to the season with a 2-1 win at the Stade Velodrome.
Lucas Mendes had given the home side a deserved lead on 43 minutes, but the big spenders hit back in the second half with goals from Radamel Falcao and substitute Emmanuel Riviere.
Claudio Ranieri’s side began well and should have taken the lead on 12 minutes when Enzo Carrasco puts his shot wide from six yards out with the goal at his mercy.
But the visitors were dealt a blow when playmaker Jeremy Toulalan went off with an injury and Marseille capitalised.
Gignac and the dangerous Ayew both fired shots inches wide from the edge of the box.
And the hosts broke the deadlock on 43 minutes when Mendez, on for the injured Diawara, fired in a header from Valbuena’s corner.
The visitors improved slightly after the break and equalised on 46 minutes when Marseille went to sleep the back, allowing Falcao to tap in from two yards out from Kurzawa’s cross.
But the Marseille onslaught continued led by winger Ayew, who struck the post after cutting inside after another mazy run while minutes later Gignac blazed an effort over from the edge of the box.
Against the run of play, the visitors hit the woodwork when Kurzawa’s glancing header struck the post on 62 minutes.
Falcao was substituted 18 minutes from time having had treatment for an ankle injury.
But that did not affect Monaco and sub Riviere should have scored after being put through.
But he redeemed himself on 79 minutes when he raced past his marker to fire the ball across Mandanda for his fifth goal of the season.
Marseille ran out of steam in the latter stages with Monaco creating the better chances, the best fell to Enzo-Carrasco who blazed over from the edge of the box as they held on to go top of the table.
In the day's early kickoff, St Etienne defeated Bordeaux 2-1, and now trail Marseille on goal difference.
Champions Paris St Germain are fourth, one point behind, after beating promoted-side Guingamp thanks to two injury-time goals by Adrien Rabiot and Zlatan Ibrahimovic.
Emmanuel Rivière scores his fifth goal in four games after coming off the bench for Falcao
Marseille suffered only their second defeat in their last 16 league games.
We saw the best and worst of Falcao tonight. In the first half he was isolated and cut a frustrated figure. In the second half, he took his chance which was presented to him on a plate before going off with an ankle injury.
MAN OF THE MATCH – Andre Ayew (Marseille).
PLAYER RATINGS -
MARSEILLE: Mandanda 7, Fanni 6, N’Koulou 5, Diawara 3, Mendy 5, Romao 5, Imbula 5, Payet 6, Valbuena 7, Ayew 7, Gignac 7. Subs: Mendes 7, Khlifa 4, Ayew 4.
MONACO: Subasic 6, Fabinho 7, Carvalho 6, Abidal 4, Kurzawa 6, Obbadi 5, Toulalan 4, Ocampos 5, Moutinho 6, Ferreira-Carrasco 6, Falcao 6. Subs: Raggi, Romero 4, Riviere 7, Pi 5.