The match marked the presentation of the team to the fans at the Stadio Luigi Ferraris, so former Coaches Mimmo Di Carlo, Gigi Del Neri, Walter Novellino and Beppe Iachini were in the stands.
Andre-Pierre Gignac opened the scoring when he pounced on a defensive mix-up between Shkodran Mustafi, Angelo Palombo and goalkeeper Da Costa.
The Blucerchiati fought back with an extraordinary three goals in five minutes, two of them from Manolo Gabbiadini and another by Eder.
Renan decided the match late on with a fierce strike to give Sampdoria the 4-3 win.
Sampdoria 4-3 Olympique Marseille
Scorers: Gignac 5 (OM), Eder 24 (S), Gabbiadini 26 (S), Valbuena 53 (OM), Fanni 54 (OM), Renan 84 (S)
Sampdoria: Da Costa (Tozzo 67); Mustafi (Berardi 60), Palombo (Salamon 62), Castellini (Fornasier 46); De Silvestri (Gavazzi 77), Eramo (Rodriguez 62), Krsticic (Gentsoglou 60), Obiang (Renan 62), Regini; Eder (Pozzi 55), Gabbiadini (Sansone 46)
Olympique Marseille: Mandanda; Fanni, Nkoulou, Mendes (Diawara 62), Mendy (Morel 85); Romao, Valbuena (Sougou 85), Imbula; Payet, Gignac (J Ayew 71), A Ayew