Both players missed the Champions League 1-0 home loss to Bayern Munich on Tuesday. Right back Debuchy was suspended and centre-half Marko Basa was ruled out after he broke his nose while heading a late equaliser at Girondins Bordeaux last weekend.
Lille are 11th on 11 points while neighbours Valenciennes, who have scored 12 goals in their last three games, are fifth on 15.
Promoted Stade Reims's best scorer Gaetan Courtet has been sidelined for six weeks after he tore a left ankle ligament last weekend.
Courtet had scored four goals in the last five league games, playing a key part in his club's good start to the season.
Reims, seventh on 14 points, host 19th-ranked Troyes on Saturday.
Eighth-placed Lorient will be without suspended full back Arnaud Le Lan and forward Innocent Emeghara.
Ajaccio's playmaker Johan Cavalli has been suspended for four games after his dispute with Bastia's Gael Angoula sparked a mass brawl and violent incidents between both sides' fans last weekend at Ajaccio.
Angoula has received a similar ban and will serve the first match of his suspension against sixth-placed Girondins Bordeaux on Sunday.