Udinese are without forward Antonio Floro Flores who is suspended.
Marius Stankevicius, Miroslav Klose, Senad Lulic, Hernanes and Christian Brocchi are out injured for Lazio.
Francesco Guidolin: "This is certainly a very important match and a playoff for third place, so that must give us extra motivation. For the second year running we are right up there challenging for a place in the Champions League. If we do not win, then our hopes for third are notably damaged. Therefore, this is the game. As for the Europa League, that is still open to us."
Edy Reja: "We still have four games to play and I hope we can achieve our aim at the end, we can still make it, even if we've had some difficulties recently. We have 15 more days to achieve our goal and we can still make it, we're still ahead of the other teams fighting for the third position on the table, so we still have that gap.
This will be the 66th Serie A meeting between these two sides: Lazio lead by 26 wins to 21, with 18 draws.
Only against Atalanta (22), have Udinese won more games than against Lazio in Serie A.
Lazio are the Italian team against which Udinese have scored the most goals in the top-flight (93).
Udinese have scored in each of their last 10 meetings against Lazio in the league.
However, the Friulani have beaten Lazio just once in their last five meetings in this competition.
Three of the last four meetings at the Friuli have ended as draws, with the hosts winning the other 2-1.
Only against Roma (11) has Antonio Di Natale scored more goals than he has done against Lazio (10) so far in Serie A.
Udinese have won just one of their last nine league fixtures, while Lazio are winless in their last three games.
The Biancocelesti have lost six of their last seven games on the road, including the last four.
Over these last seven away games, Lazio have failed to keep a single clean sheet (17 goals conceded in total).
Pablo Armero has already made 10 assists – only Miccoli (12) and Pirlo (11) have delivered more in this campaign.
Udinese 11/10, Lazio 5/2, Draw 23/10.