Goals from Wesley Sneijder, Diego Milito and substitute Philippe Coutinho ensured that Inter Milan sealed all three points.
Inter were expected to have little trouble seeing off a Pescara side many tipped to find life difficult in Italy’s top flight.
It looked to be the perfect opening fixture for a side who had finished a lowly sixth last season, employing three different managers and losing 14 league games in the process.
They took the lead, admittedly against the run of play, in the 17th minute as Javier Zanetti feed Diego Milito, whose pass across the Pescara box was swept home by Sneijder.
Two minutes later and another flowing move undid the home side as Sneijder played in new signing Antonio Cassano, whose square pass was slammed home by Milito.
It was tough on Pescara who began the match on the front foot and could easily have been ahead had Luca Castellazzi not produced a strong one-handed save in the 15th minute to palm over Gianluca Caprari’s free-kick.
Shortly before that chance, the hosts were unlucky not to find themselves awarded a penalty as Zanetti brought down the adventurous Vladimir Weiss in the Inter penalty box.
The referee felt that the Slovakian, on loan from Manchester City, had dived - but replays appeared to show that contact had been made by Zanetti.
Although the two Inter goals initially shocked Pescara, they regained their composure with Walter Gargano called upon to turn away Jonathas’ dangerous right-wing cross with Emmanuel Cascione lurking.
Then, just after the half-hour mark, Caprari sent a low strike just wide of Castellazzi’s far post.
Whether the Inter goalkeeper would have reached that effort was questionable, but there was no doubting his superb one-handed save to claw Cascione’s downward header around his post shortly before half-time.
Even with that mounting Pescara pressure, Inter began the second-half with the advantage in the scoreline and that showed as they started to fully assert themselves in the contest.
Pescara keeper Mattia Perrin was called on to quickly cut out an opportunity for Guarin after the Colombian was played in by Milito on the hour mark, and that chance swiftly followed an Esteban Cambiasso header that flew over the home side’s goal from just a few yards out.
When Simone Romagnoli was forced into a last-ditch tackle to prevent Milito from firing at the Pescara goal, the fear that the game was slipping further away from the hosts became all the more real.
Pescara looked devoid of ideas as the match worn on, with Inter's greater attacking threat negating their desire to press forward in greater numbers and haul themselves back into the match.
Milito should have put the match beyond doubt when Coutinho played him in. However, the Argentine side-footed his 75th minute attempt over Perin’s goal.
But he did make amends for that glaring miss inside the final ten minutes, as Milito’s low pass from the right was drilled in by Brazilian Coutinho to wrap up the victory for Inter.