Game Five is in New York on Thursday when the Knicks will have to win to stay alive in the series, while the Pacers can reach the Eastern Conference Finals for the first time since the 2003-04 season.
The Knicks, who scored just 71 points in an 11-point loss on Saturday, failed to show much sign of urgency on Tuesday and trailed by 14 at halftime.
George Hill scored 26 points for Indiana, who outrebounded the Knicks 54-36 and held them to just 35 percent shooting from the field.
Carmelo Anthony scored a team-high 24 points and had nine rebounds but made just nine of 23 shots, while a misfiring J.R. Smith shot 7-for-22.
Paul George added 18 points, 14 rebounds and seven assists for Indiana, who are a perfect 5-0 at home in the playoffs.
The San Antonio Spurs routed visiting Golden State 109-91 on Tuesday to grab a 3-2 lead in the Western Conference second round series.
The Spurs had squandered an eight-point advantage in the fourth quarter of Game Four to let the Warriors even the series, but they much more clinical back at home in the AT&T Center where they only briefly trailed in the first quarter.
Tony Parker recorded 25 points and 10 assists while Tim Duncan had 14 points and 11 rebounds for the Spurs, who will try to close out the series in Game Six on Thursday at Golden State.
Harrison Barnes led the Warriors with 25 points and Jarrett Jack had 20 but Stephen Curry and Klay Thompson, who had erupted for huge games earlier in the Western Conference semi-final, combined for 13 points and made one three-pointer between them.