Buccaneers offensive guard Carl Nicks was recently diagnosed with a recurrence of MRSA, with cornerback Jonathan Banks also having suffered the illness this week.
Kicker Lawrence Tynes also got the infection in the summer.
The Philadelphia Daily News said the NFL, the only entity that can postpone a game, has no plans to do so.
The NFLPA could theoretically tell the players not to play, but NFL.com's Ian Rapoport indicated that would not happen either.
"The belief is that there is no additional risk to players and no determination that the infection currently exists in Bucs stadium facility," he added.
Even if Sunday's game is not affected, the Buccaneers could have a significant problem.
The infection, a powerful bacteria that is resistant to some penicillin treatments, came back despite the team sanitising their medical facility in August.
"As in anything, I think so much of the fear is the unknown, so as we became better educated, we all kind of understand the gameplan of how to make sure this doesn't become a bigger problem," Bucs coach Greg Schiano said.
"We'll move some guys around, if need be. I don't know what the final outcome is going to be on all the situations.
"I'm not going to lock in anything in my mind right now, other than have flexibility, other than that's why you train guys with the first-team guy, the second-team guy, or some mix or match of both."