The 22-year-old reached her first final at the Nationals in 2009, that coming in the women's doubles with Jenny Wallwork where they lost to Donna Kellogg and Suzanne Rayappan.
However, since then White hasn't failed to leave the tournament without a title having won the women's doubles crown with Wallwork for the past three years running.
White made it a double last year by winning the mixed doubles for the first time ever with fiancé Chris Adcock, who she is now back with permanently after a break.
This year, however, White isn't teaming up with Wallwork, changes giving them separate mixed doubles partners in Lauren Smith and Alex Langley respectively.
The Nationals will also mark White and Adcock's first since being partnered back together and the former wants another double in Manchester.
"Chris and I won at the Nationals last year and that was really great. I also got the women's doubles title with Jenny so it's a competition I enjoy going to," said White.
"I think everyone likes going there and winning and I'm no different. Any event is going to be competitive when it's a National Championship.
"It's a shame for me this year because Jenny and I won't be able to defend our title. Things are always being mixed up, so now I'm with Lauren.
"I'm excited by the new partnership but it's always a big shame when you aren't able to go and defend a former title so it was disappointing.
"We had the chance to be the first to win it for four years in a row. It will be good to link up with Lauren, though, and hopefully we can do really well."
White and Adcock start as second seeds in the mixed doubles and face James Lauder and Zoe Hallam first up in the second round while she will also start as second seeds with Smith in the women's doubles.